[Rejuran I for Eye Wrinkles] Fine Lines and Dark Circles on Thin, Delicate Eye Skin, Improved Naturally Without a Frozen Look: The PN Skin Booster Treatment
Hello. I'm Dr. Dongmin Lee of Ruby Dermatology Clinic, where we use refined medical care to enhance the natural harmony of each person's features.
"I'm worried about the fine lines and crow's feet around my eyes, which are getting more noticeable. The skin there is so thin that I'm afraid regular fillers would leave bumps or make my expression look unnatural. Is there a safe way to restore firmness?"
This is one of the most common and very real concerns shared by patients who come to my clinic about aging around the eyes.
The eye area is the thinnest skin on the face (about 0.5 mm) and an anatomically very sensitive area where the muscles of expression are in constant motion. Instead of forcing in physical volume that can leave the area looking puffy, this area calls for Rejuran I, an approach that uses highly concentrated PN (polynucleotide) derived from salmon DNA to rebuild the dermal structure around the eyes and help the skin restore its own thickness.
💡 [3-Point Summary]
Why aging around the eyes is different: The skin around the eyes is very thin and has few oil glands, so it dries out and forms fine lines easily. Botox or standard fillers there carry a higher risk of altering the shape of the eyes or causing puffiness (the Tyndall effect).
How Rejuran I (PN) works: This eye-specific PN formulation has a low viscosity and spreads flexibly. It supplies biological building materials to damaged dermal cells, thickening the dermis around the eyes and stimulating the skin's own collagen regeneration.
Customized injection and combination protocols: Using a microinjection technique, it improves fine lines under the eyes, at the outer corners and on the eyelids without any foreign-body feeling, and delivers amplified synergy when combined with eye-area skin Botox or laser treatments.
A. Why Should Eye Wrinkle Treatment Differ from Standard Fillers or Botox?
Approaching eye wrinkles simply by paralyzing muscles or filling in space can easily lead to an unnatural-looking expression.
Limits of Botox (an unnatural look around the eyes):
Eye-area Botox relaxes the orbicularis oculi, the muscle that closes the eye, to soften wrinkles. Overdone, it can make the eyes look awkward when you smile or leave the under-eye area looking hollow.
Limits of Standard HA Fillers (puffiness and the Tyndall effect):
Because the dermis under the eyes is so thin, injecting a standard HA filler with high water-binding capacity can make the area swell and look puffy as it absorbs water, or cause the Tyndall effect, where light scattering gives the skin a bluish tint.
B. Anatomical Advantages of Rejuran I
Eye-specific molecular viscosity and elasticity:
Its viscosity is lower than that of the original Rejuran Healer, so even when injected into thin eye-area skin, embossing marks (wheals) settle quickly and the product spreads smoothly without clumping.
Dermal structure rebuilding and self-thickening:
The highly biocompatible PN activates fibroblasts and increases dermal density, restoring the thinned skin around the eyes so it becomes firmer and thicker.
Improved eye-area microvascular environment (softening dark circles):
By promoting new blood vessel growth and strengthening the dermal basement membrane, it naturally improves vascular-type dark circles, where tiny vessels show through thinned skin.
C. Rejuran Healer vs. Rejuran I at a Glance
| Category | Rejuran Healer | Rejuran I |
|---|---|---|
| Primary Treatment Areas | Full face, cheeks, forehead, jawline | Around the eyes, under-eyes, outer corners of the eyes, and eyelids (thin skin areas) |
| Product Viscosity / Fluidity | Medium viscosity (supports firm dermal regeneration) | Low viscosity (high fluidity for better spreadability in thin skin areas) |
| Duration of Embossing (Post-Injection Bumps) | Remains visible for approximately 24–48 hours | Typically subsides naturally within 12–24 hours |
| Key Benefits | Overall oil-moisture balance, skin texture, and elasticity | Fine lines around the eyes, improved thickness of thin under-eye skin, and dark circles |
D. Recommended Treatment Schedule and Recovery
Recommended schedule: For solid rebuilding of the dermis around the eyes, we recommend 3–4 or more sessions at 2–3 week intervals.
Downtime / recovery: Thanks to the lower viscosity, most residual embossing fades within 12 hours, and you can wear light makeup and resume daily activities the next day.
E. 🔥 Complete Anti-Aging for the Eyes: the 'Ruby Eye Refresh' Synergy
Rejuran I + Eye-Area Micro Skin Botox:
Rejuran I thickens and fills the thinned dermis, while skin Botox finely softens the shallow expression lines on the surface, giving you taut, firm eyes without an unnatural expression.
Rejuran I + Eye Oligio / Eye Icon (RF radiofrequency):
After radiofrequency energy first tightens the collagen in the dermis around the eyes, injecting Rejuran I boosts dermal density and elasticity for a synergistic effect.

F. Dr. Dongmin Lee's Practical Know-How & Clinical Insights
The skin around the eyes is under 1 mm thick, a very delicate area, so the result depends on 'a microinjection technique that precisely targets the upper-to-mid dermis and deposits the product at a consistent depth, like threading beads.'
Before treatment, I carefully assess each patient's type of eye wrinkles (expression lines, dryness-related fine lines, skin thinning) and the distribution of the delicate blood vessels around the eyes that are prone to bruising. I use an ultra-fine 34G 3-point nano needle to minimize pain and bruising, and apply the '3D Focus Eye Nano-Mapping' technique, which builds embossing in fine micro-units under the eyes and at the outer corners. This delivers smooth, refreshed-looking eyes with a seamless, natural result and no unnatural expression.
📌 [Final Notes] Pre- and Post-Treatment Precautions
Avoid rubbing your eyes: For 2–3 days after treatment, do not rub or press hard on the eye area so the injected PN can settle evenly.
Sun protection and hydration: The skin around the eyes is prone to pigmentation, so apply sunscreen thoroughly whenever you go out, and use a gentle moisturizer made for the eye area.
Avoid alcohol and strenuous exercise: To prevent lingering bruising and swelling, avoid heavy drinking, saunas and vigorous exercise for 3–5 days after treatment.
About the Author
Dr. LEE Dongmin
Ruby Dermatology Clinic
After graduating from Korea University College of Medicine, Dr. Lee served as director of U&I Clinic and of Ruby Plastic Surgery, and is now director of Ruby Dermatology Clinic, dedicated to restoring each patient's natural skin health and beautiful contours.
Korea University, College of Medicine (M.D.)
Member of Korean Society of Filler
Member of Korean Society of Laser, Dermatology and Hair
Member of Korean Society of Obesity and Aesthetic Medicine
Former Doctor, RUBY Plastic Surgery, U&I Clinic
